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-synuclein, which can be a key component of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, which can be an E3 ubiquitin ligase and will cause endoplasmic reticulum (ER) pressure, counsel that dysfunction in the intracellular proteinase units, for instance ubiquitin-proteasome procedure or lysosomal method, which eliminates avoidable h

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